Ongoing ESOTA Trials
The aim of the Trials Network Committee is to facilitate academic clinical stroke research in Europe.
Within the networks various trials are actively recruiting. We would like to refer to the ‘Member Networks’ page to find more information about clinical studies within each network. Below you can find a link to clinicaltrials.gov which contains an overview of clinical stroke trials in all European countries.
Infortmation concerning funding and insurance can be found here.
Investigators will find the following resources:
1.
Database of ongoing stroke research: A repository of > 100 ongoing clinical stroke studies running in two or more European countries, including information about the coordinating investigators behind these trials. [click here]
2.
Existing trials collaborating with ESOTA networks
Trials in planning phase collaborating with ESOTA networks
TICH-3
PI: Prof Nikola Sprigg, U Nottingham – UK
Tranexamic acid vs placebo for acute non-traumatic ICH <4.5 hours onset
Overall 392 participants
UK 306 participants have been recruited.
56 UK sites are opened and 52 of these have recruited.
For TICH-3 International, 82 participants have been recruited and there are 19 sites opened: Malaysia: 13, Georgia:3, Denmark: 1, Finland:1, Italy:1
Out of the 19 sites, 14 have recruited. Recruitment open in Italy, Denmark, Finland.
Sites to pen in Ireland, Spain, France, Swizerland soon.
Additional countries sites welcome only if able to secure funding locally.
New sites/investigators contact tich-3@nottingham.ac.uk
ASPIRING (Antiplatelet Secondary Prevention International Randomised trial after Intracerebral haemorrhage)
PI: Prof Rustam al-Shahi Salman, University of Edinburg – UK
The Antiplatelet Secondary Prevention International Randomised trial after INtracerebral haemorrhaGe (ASPIRING) is funded to start in 2024 in the UK, Canada, The Netherlands, and Australia with funding via the GCRFF Multinational Clinical Trials initiative from the British Heart Foundation, Canadian Institutes of Health Research, Dutch Heart Foundation, and National Health and Medical Research Council Medical Research Future Fund respectively.
(Status August 2023)
European blood pressure intensive control after stroke – pilot trial (EPICS-Pilot)
PI: Prof Peter Kelly, University College Dublin – Ireland
ethics applications are underway; aim for first patient is Oct/Nov 2023 (Status: August 2023)
Pharyngeal electrical stimulation for dysphagia after stroke (PhEAST-3)
PI: Professor Philip M Bath, University of Nottingham – UK
ethics applications are underway; aim for first patient is Oct/Nov 2023 (Status: August 2023)
DO-IT Thrombolysis in patients treated with NOACS (DO-IT)
PI: Dr Thomas Meinel, University of Bern – Switzerland
Dutch ICH Surgery Trial (DIST)
PI: Prof. Dr. Karin Klijn, Radboud University Medical Center – The Netherlands
Additional ongoing stroke randomised trials in Europe
Other European networks and GAINS
BeNET – Belgian Network for Clinical Stroke Trials
Czech Stroke Research Network – STROCZECH
HRB Stroke Clinical Trials Network Ireland
Hellenic Society of Cerebrovascular Diseases Clinical Trial Network (HSCVDCTN)
Italian Stroke Research Network
UK Stroke Clinical research network
Scottish Stroke Research Network
TurkStrokeNet – Turkish Stroke Research and Clinical Trials Network
European Clinical Research Infrastructure Network