Ongoing ESOTA Trials
The aim of the Trials Network Committee is to facilitate academic clinical stroke research in Europe.
Within the networks various trials are actively recruiting. We would like to refer to the ‘Member Networks’ page to find more information about clinical studies within each network. Below you can find a link to clinicaltrials.gov which contains an overview of clinical stroke trials in all European countries.
We would also like to inform researchers about funding opportunities in Europe and information about insurance arrangements. These documents are currently being updated and will be uploaded shortly.
Investigators will find the following resources:
1.
Database of ongoing stroke research: A repository of > 100 ongoing clinical stroke studies running in two or more European countries, including information about the coordinating investigators behind these trials. [click here]
2.
Information about regulatory systems: Overview of competent authorities and research ethics committees in Europe, with links to the legislation for clinical trials in the different countries. [click here]
3.
Information about insurance arrangements: Overview of insurance arrangements for multi-national clinical trials. [click here]
4.
An overview of relevant courses and other resources organised and provided by each network can be found on the webpages of the national networks. [click here]
Existing trials collaborating with ESOTA networks
COIchine for prevention of Vascular Inflammation in Non-CardioEmbolic stroke (CONVINCE)
PI: Prof Peter Kelly, U College Dublin – Irelland
Colchicine plus usal care versus usal care alone after ischaemic stroke
Status: 1,928 patients randomized (May 2021)
Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillation (ELAN)
PI: Prof Urs Fischer, Inselspital (University Hospital) Bern – Switzerland
Early versus guideline-based introduction of direct oral anticoagulants after ischaemic stroke with atrial fibrillation
Status: 730 patients randomized (May 2021)
Trials in planning phase collaborating with ESOTA networks
TICH-3
PI: Prof Nikola Sprigg, U Nottingham – UK
Tranexamic acid vs placebo for acute non-traumatic ICH
Status: funding application submitted (May 2021)
ASPIRING (Antiplatelet Secondary Prevention International Randomised trial after Intracerebralhaemorrhage)
PI: Prof Rustam al-Shahi Salman, University of Edinburg – UK
Antiplatelet therapy versus usual care for prevention of occlusive vascular events after ICH
Status: funding applications under way (May 2021)
European blood pressure intensive control after stroke – pilot trial (EPICS-Pilot)
PI: Prof Peter Kelly, University College Dublin – Ireland
Intensive versus guideline-based systolic blood pressure reduction after ischaemic stroke
Status: funding application submitted (May 2021)
Additional ongoing stroke randomised trials in Europe
Other European networks and GAINS
